Report on a Fatal Case of Agranulocytosis

Fatal agranulocytosis due to phenylindanedione: report of a case.

PHENYLINDANEDIONE is one of several oral anticoagulants in wide use at the present time. It is generally considered to be non-toxic, but adverse reactions to the drug have been reported. We have been able to find six instances of agranulocytosis, two of jaundice,' and six of rash without fever 13 in the world literature. One of the instances of agranulocytosis was fatal. The purpose of this com...

Benazepril-Induced Agranulocytosis: A Case Report and Review of the Literature

BACKGROUND Angiotensin-converting enzyme inhibitors are widely used drugs, and in appropriately selected patients, serious side effects are infrequent. Commonly seen side effects include cough, rash, hyperkalemia, renal dysfunction, and angioedema. Historically, dose-related agranulocytosis has been associated with captopril. Benazepril, a relatively more potent angiotensin-converting enzyme in...

Chronic idiopathic agranulocytosis; report of a fatal case treated with corticotrophin (ACTH).

Unrecognized clozapine-related constipation leading to fatal intra-abdominal sepsis – a case report

Clozapine is the preferred antipsychotic used for the treatment of resistant schizophrenia with suicidal ideation. The drug is started at a low dose and gradually increased to a target dose of 300-450 mg/day. It is well known to cause agranulocytosis and neutropenia. Several cases of fatal sepsis have been reported in neutropenic patients and emphasis is placed on monitoring for agranulocytosis...

A drug-specific leuco-agglutinin in a fatal case of agranulocytosis due to chlorpromazine.

A fatal case of agranulocytosis due to chlorpromazine is reported. Mechanisms other than immunological are generally believed to be responsible for chlorpromazine-induced agranulocytosis. However, the demonstration of a drug-specific leuco-agglutinin in the serum of this patient suggests that an immunological mechanism was responsible for the agranulocytosis.